The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2021
Filed:
Nov. 07, 2019
Applicant:
Northwestern University, Evanston, IL (US);
Inventors:
Dimitri Krainc, Chicago, IL (US);
Richard B. Silverman, Winnetka, IL (US);
Jianbin Zheng, Evanston, IL (US);
Assignee:
Northwestern University, Evanston, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); A61K 38/47 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 417/14 (2006.01); C07D 413/14 (2006.01); C07D 497/04 (2006.01); C07D 487/08 (2006.01); C07D 239/94 (2006.01); C07D 409/04 (2006.01); C07D 405/04 (2006.01); C12N 9/24 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 38/47 (2013.01); C07D 239/94 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/08 (2013.01); C07D 495/04 (2013.01); C07D 497/04 (2013.01); C12N 9/2402 (2013.01); C12Y 302/01045 (2013.01);
Abstract
Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.