The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2021
Filed:
Nov. 05, 2018
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
James E. Dahlman, Cambridge, MA (US);
Avraham D. Schroeder, Newton, MA (US);
Daniel Griffith Anderson, Framingham, MA (US);
Robert S. Langer, Newton, MA (US);
Christopher G. Levins, Flemington, NJ (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/22 (2006.01); A61K 47/54 (2017.01); A61K 47/59 (2017.01); A61K 47/69 (2017.01); C07D 257/02 (2006.01); C07D 273/08 (2006.01); A61K 9/00 (2006.01); A61K 47/34 (2017.01); C08G 73/10 (2006.01); A61K 9/127 (2006.01); C07D 273/00 (2006.01); C07D 295/084 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/22 (2013.01); A61K 9/0019 (2013.01); A61K 9/1272 (2013.01); A61K 47/34 (2013.01); A61K 47/543 (2017.08); A61K 47/59 (2017.08); A61K 47/6907 (2017.08); A61K 47/6911 (2017.08); A61K 47/6921 (2017.08); C07D 257/02 (2013.01); C07D 273/00 (2013.01); C07D 273/08 (2013.01); C07D 295/084 (2013.01); C08G 73/10 (2013.01); C12N 15/1137 (2013.01); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as 'conjugated lipomers' or 'lipomers') containing one or more groups of the formula (iii): wherein Rand Rare as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.