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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10933093 B1

PDFFull Text
Expired
Date of Patent:
Mar. 02, 2021

Filed:

Apr. 10, 2018

Compositions and methods of treating a t cell mediated disorder

Applicant:

Case Western Reserve University, Cleveland, OH (US);

Inventors:

M. Edward Medof, Cleveland, OH (US);

Feng Lin, Cleveland, OH (US);

Michael G. Strainic, Cleveland, OH (US);

Assignee:

CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);

Attorney:

Tarolli, Sundheim, Covell & Tummino LLP

Primary Examiner:

Amy E Juedes

Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); A61K 38/00 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C12N 5/0636 (2013.01); A61K 38/00 (2013.01); A61K 2035/122 (2013.01); A61K 2035/124 (2013.01); C12N 2501/998 (2013.01);
Abstract

A method of generating a CD4FoxP3Treg cell, the method includes administering at least one complement antagonist to a naive CD4T cell at an amount effective to substantially inhibits C3a receptor (C3aR) and/or C5a receptor (C5aR) signal transduction in the CD4T cell, induce TGF-β1 expression of the CD4T cell, and induce differentiation of the of the naive CD4T cell into a CD4FoxP3Treg cell.

Find Patent Forward Citations

Medof, M.. (2021). Compositions and methods of treating a t cell mediated disorder (U.S. Patent No. 10933093). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10933093

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