The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2021
Filed:
Nov. 21, 2017
Applicant:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Inventors:
Joe Salas, Wayland, MA (US);
Robert T. Peters, Needham, MA (US);
Assignee:
BIOVERATIV THERAPEUTICS INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/96 (2006.01); C12N 9/64 (2006.01); C07K 14/745 (2006.01); C07K 16/28 (2006.01); C07K 14/755 (2006.01); C07K 16/18 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/644 (2013.01); C07K 14/745 (2013.01); C07K 14/755 (2013.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/2848 (2013.01); C12N 9/647 (2013.01); C12N 9/6432 (2013.01); C12N 9/6437 (2013.01); C12N 9/96 (2013.01); C12Y 304/21021 (2013.01); C12Y 304/21022 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01);
Abstract
The present invention features inter alia nucleic acid molecules which encode polypeptides comprising a single chain Fc region and the polypeptides they encode. The Fc moieties of these constructs are linked by a cleavable scFc linker which is adjacent to at least one enzymatic cleavage site, e.g., an intracellular processing site. The resulting processed molecules comprise two polypeptide chains and substantially lack the extraneous amino acid sequence found in single chain Fc linker molecule. Methods of making and using these dimeric molecules are also described.