The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2021
Filed:
Jul. 08, 2015
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Lili Yang, Los Angeles, CA (US);
Drake J. Smith, Los Angeles, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C12N 5/0783 (2010.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 48/00 (2013.01); C07K 14/70503 (2013.01); C12N 5/0646 (2013.01); A61K 2039/5154 (2013.01); C12N 2506/11 (2013.01); C12N 2510/00 (2013.01); C12N 2740/13043 (2013.01); C12N 2830/48 (2013.01);
Abstract
Disclosed are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof. Specifically, the engineered cells iNKT are genetically modified to contain at least one exogenous invariant natural killer T cell receptor (iNKT TCR) nucleic acid molecule. Further disclosed are iNKT TCR nucleotide sequences and codon optimized sequences for expression.