The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2021
Filed:
Dec. 20, 2019
Applicant:
Southwest Research Institute, San Antonio, TX (US);
Inventors:
William R. Cantrell, Jr., San Antonio, TX (US);
Robert D. Gutierrez, San Antonio, TX (US);
Michael J. Rubal, Lytle, TX (US);
Assignee:
Southwest Research Institute, San Antonio, TX (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
C07D 489/08 (2013.01);
Abstract
Methods for removing residual solvent from Nalmefene Hydrochloride (HCl) and producing crystalline Nalmefene HCl monohydrate, monosolvate or crystalline Nalmefene HCl dihydrate are described. In embodiments, the methods include recrystallizing Nalmefene HCl from a solvate that includes Nalmefene HCl, water, and a first solvent, wherein the first solvent has a molar volume of at least 98 cm. Crystalline Nalmefene HCl with a desirably low amount of residual solvent is also described.