The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2021
Filed:
May. 30, 2017
Inje University Industry-academic Cooperation Foundation, Gimhae-si, KR;
Jin Han, Busan, KR;
Seung Hun Jeong, Busan, KR;
In-Sung Song, Yangsan-si, KR;
Hyoung Kyu Kim, Busan, KR;
Nari Kim, Busan, KR;
Larisa K. Shubina, Vladivostok, RU;
Tatyana N. Makarieva, Vladivostok, RU;
Valentin A. Stonik, Vladivostok, RU;
Dmitry V. Yashunsky, Moscow, RU;
Nikolay E. Nifantiev, Moscow, RU;
INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Gimhae-si, KR;
Abstract
The present invention relates to novel pyridine nucleoside compounds, Neopetroside A (NPS A) and Neopetroside B (NPS B) obtained by fractionating an extract ofsp. which is a marine sponge, with ethanol, into n-butanol (n-BuOH). When the NPS A was treated with myocardial cells, it activates oxidative phosphorylation, basal and mitochondrial respiration induced by ATP and ATP synthesis, and stimulates the glycolysis activity and when the NPS A was treated with an ischemic reperfusion injury model, the left ventricular pressure injured by ischemic reperfusion was recovered and the size of myocardial injury site was significantly reduced and as a result, can be provided as the pharmaceutical composition for preventing or treating ischemic heart disease or the health functional food for preventing or improving the same.