The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 23, 2021

Filed:

Jul. 02, 2014
Applicants:

Bracco Suisse S.a., Manno, CH;

Koninklijke Philips N.v., Eindhoven, NL;

Inventors:

Jeffry Earl Powers, Bainbridge Island, WA (US);

Ralf Seip, Carmel, NY (US);

William Tao Shi, Briarcliff Manor, NY (US);

Francois Tranquart, Nernier, FR;

Yannick Bohren, Renens, CH;

Emmanuel Jean-Marie Gaud, La Croix-de-Rozon, CH;

Ebeline Bihel, Plan les Quates, CH;

Feng Yan, Grand-Lancy, CH;

Marcel Arditi, Aire, CH;

Jean-Marc Paul Robert Hyvelin, Geneva, CH;

Assignees:

KONINKLIJKE PHILIPS N.V., Eindhoven, NL;

BRACCO SUISSE SA, Manno, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 7/00 (2006.01); A61B 8/08 (2006.01); A61B 17/22 (2006.01);
U.S. Cl.
CPC ...
A61N 7/00 (2013.01); A61B 8/0833 (2013.01); A61B 17/22004 (2013.01); A61B 8/483 (2013.01); A61B 8/5246 (2013.01); A61B 2017/22007 (2013.01); A61B 2017/22008 (2013.01); A61N 2007/0004 (2013.01); A61N 2007/0039 (2013.01); A61N 2007/0052 (2013.01); A61N 2007/0078 (2013.01); A61N 2007/0086 (2013.01);
Abstract

Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.


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