The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2021
Filed:
Feb. 09, 2018
Applicant:
Oncology Research International Limited, Perth, AU;
Inventors:
Peter Kelly, Lower Hutt, NZ;
Philip Andrew Marshall, Tennyson, AU;
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 71/00 (2006.01); C07J 19/00 (2006.01); A61K 31/7048 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7048 (2013.01); A61P 35/00 (2018.01); C07J 19/00 (2013.01); C07J 71/00 (2013.01); C07J 71/0005 (2013.01);
Abstract
The present invention relates to a new class of steroid saponins that have interesting biological activity. In particular the present invention relates to a class of steroid saponins in which the sugar moiety has been selectively functionalised to introduce a moiety that contains either, (i) a hydrogen ion donor, (ii) a hydrogen ion acceptor or (iii) a combination thereof. These new, water-soluble compounds are found to not only have potent anti-cancer properties per se but also have the ability to promote the immune response in a subject and can thus act as adjuvants for T-cell activation in cancer therapy.