The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 16, 2021

Filed:

Jan. 13, 2017
Applicant:

Japanese Foundation for Cancer Research, Tokyo, JP;

Inventors:

Kengo Takeuchi, Tokyo, JP;

Seiji Sakata, Tokyo, JP;

Yuki Togashi, Tokyo, JP;

Naoya Fujita, Tokyo, JP;

Ryohei Katayama, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12Q 1/68 (2018.01); G01N 33/50 (2006.01); C12N 9/12 (2006.01); G01N 33/574 (2006.01); C12N 9/88 (2006.01); C07K 14/82 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01); A61K 38/00 (2006.01); C12N 15/113 (2010.01); C12N 15/62 (2006.01); C12Q 1/6886 (2018.01); C12Q 1/6853 (2018.01); C12Q 1/686 (2018.01);
U.S. Cl.
CPC ...
G01N 33/5011 (2013.01); A61K 31/519 (2013.01); A61K 38/005 (2013.01); A61P 35/00 (2018.01); C07K 14/82 (2013.01); C12N 9/12 (2013.01); C12N 9/88 (2013.01); C12N 15/113 (2013.01); C12N 15/62 (2013.01); C12Y 207/11025 (2013.01); C12Y 402/01047 (2013.01); G01N 33/57446 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6853 (2013.01); C12Q 1/6886 (2013.01);
Abstract

It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.


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