The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Feb. 01, 2016
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Universite DE Montpellier, Montpellier, FR;
Pierre Roux, Saint Gely-du Fesc, FR;
Nikola Arsic, Montpellier, FR;
Gilles Gadea, Les Matelles, FR;
Philippe Fort, Castelnau-le-Lez, FR;
Fanny Thomas, Montpellier, FR;
Véronique Gire, Montpellier, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universite de Montpellier, Montpellier, FR;
Abstract
The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of Δ133ρ536 isoform, Δ133ρ53γ isoform, or both Δ133ρ536 and Δ133ρ53γ isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in Δ133ρ536 isoform, Δ133ρ53γ isoform, or both Δ133ρ536 and Δ133ρ53γ isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing Δ133p536 isoform, Δ133ρ53γ isoform, or both Δ133ρ536 and Δ133ρ53γ isoforms expression; and also to screening methods for anti-cancer stem cells agents.