The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 16, 2021

Filed:

May. 03, 2017
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Zev Jordan Gartner, Pacifica, CA (US);

Alex James Hughes, Berkeley, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/37 (2015.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61K 35/00 (2006.01); B33Y 10/00 (2015.01); B33Y 70/00 (2020.01); B33Y 80/00 (2015.01); A61F 2/02 (2006.01); C12M 3/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0068 (2013.01); A61F 2/022 (2013.01); A61K 35/37 (2013.01); A61L 27/3808 (2013.01); A61L 27/3813 (2013.01); A61L 27/3826 (2013.01); A61L 27/3886 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); B33Y 10/00 (2014.12); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12); C12M 21/08 (2013.01); C12N 5/0062 (2013.01); A61F 2240/001 (2013.01); A61K 35/00 (2013.01); C12N 2513/00 (2013.01); C12N 2533/12 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01); C12N 2533/90 (2013.01); C12N 2535/00 (2013.01);
Abstract

The present disclosure provides methods and systems for generating biological tissues that are configured for folding into a pre-determined three-dimensional form. The present disclosure utilizes contractile cells for folding a biological tissue into a three-dimensional shape. The methods include disposing a pattern of contractile cells on a surface that includes fibers actuated by the contractile cells and folding of the surface by the action of the contractile cells on the fibers. Tissues generated using the methods and systems of the present disclosure are also provided.


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