The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Oct. 17, 2018
Applicant:
Autolus Limited, London, GB;
Inventors:
Assignee:
AUTOLUS LIMITED, London, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 14/705 (2006.01); A61K 35/17 (2015.01); C07K 16/18 (2006.01); C12N 15/85 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70578 (2013.01); A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C07K 14/70575 (2013.01); C07K 16/18 (2013.01); C12N 15/85 (2013.01); A61K 48/00 (2013.01);
Abstract
The present invention provides a chimeric antigen receptor (CAR) comprising; (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.