The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Jun. 30, 2017
Applicant:
Suzhou Kintor Pharmaceuticals, Inc., Jiangsu, CN;
Inventor:
Xiaohu Zhang, Suzhou, CN;
Assignee:
SUZHOU KINTOR PHARMACEUTICALS, INC., Jiangsu, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 35/00 (2006.01); A61K 31/519 (2006.01); A61K 31/517 (2006.01); A61K 31/4745 (2006.01); A61K 31/5377 (2006.01); A61K 33/24 (2019.01); A61K 31/506 (2006.01); A61K 31/337 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/337 (2013.01); A61K 31/4745 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract
A chiral heterocyclic compound with hedgehog pathway antagonist activity, method and use thereof are provided. The chiral heterocyclic compound with hedgehog pathway antagonist activity has the structure represented by formula I. A pharmaceutical composition and combined application composition are also provided. Novel molecules of formula II that inhibit hedgehog pathway signaling and therapeutic applications for the treatment of malignancies, prevention of tumor regrowth, sensitization of radio-chemo therapies, and other diseases related to hedgehog signaling are also provided.