The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 16, 2021

Filed:

Jul. 14, 2016
Applicant:

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Inventors:

Olaf Panknin, Berlin, DE;

Ingo Hartung, Berlin, DE;

Hartmut Rehwinkel, Berlin, DE;

Duy Nguyen, Berlin, DE;

Ludwig Zorn, Berlin, DE;

Petra Helfrich, Falkensee, DE;

Katja Zimmermann, Düsseldorf, DE;

Roland Neuhaus, Berlin, DE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 235/30 (2006.01); C07D 471/04 (2006.01); A61P 35/00 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01); A61K 45/06 (2006.01); C12P 17/10 (2006.01);
U.S. Cl.
CPC ...
C07D 235/30 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 471/04 (2013.01); C12P 17/10 (2013.01);
Abstract

The present invention relates to compounds of general formula (I): in which R, R, R, R, R, R, R, R, R, R, R, Rand X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.


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