The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Nov. 26, 2019
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
David A. Putnam, Ithaca, NY (US);
Joseph Rosenthal, Ithaca, NY (US);
Chung-Jr Huang, Mewbury Park, CA (US);
Matthew DeLisa, Ithaca, NY (US);
Susana Mendez, Silver Spring, MD (US);
Assignee:
Cornell University, Ithaca, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2020.01); A61K 39/015 (2006.01); A61K 39/12 (2006.01); A61K 39/04 (2006.01); A61K 39/145 (2006.01); A61K 39/35 (2006.01); A61K 39/39 (2006.01); A61K 38/16 (2006.01); A61K 39/38 (2006.01); C12N 15/70 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/015 (2013.01); A61K 38/164 (2013.01); A61K 39/04 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 39/35 (2013.01); A61K 39/38 (2013.01); A61K 39/39 (2013.01); C12N 15/70 (2013.01); A61K 2039/52 (2013.01); A61K 2039/523 (2013.01); A61K 2039/6068 (2013.01); C12N 2760/16134 (2013.01); Y02A 50/30 (2018.01);
Abstract
The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.