The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Nov. 07, 2014
The Regents of the University of California, Oakland, CA (US);
The Marine Biological Laboratory, Woods Hole, MA (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Jennifer R. Morgan, Braintree, MA (US);
Gal Bitan, Culver City, CA (US);
David J. Busch, Manor, TX (US);
The Regents of the University of California, Oakland, CA (US);
The Marine Biological Laboratory, Woods Hole, MA (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.