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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10918647 B1

PDFFull Text
Date of Patent:
Feb. 16, 2021

Filed:

Jul. 26, 2017

Selective bromodomain inhibition of fungal bdf1

Applicants:

University of Southern California, Los Angeles, CA (US);

Cnrs, Paris, FR;

Universite Grenoble Alpes, Saint Martin d'Heres, FR;

Inserm, Paris, FR;

Inventors:

Charles E. McKenna, Los Angeles, CA (US);

Carlo Petosa, Paris, FR;

Jerome Govin, Paris, FR;

Boris A. Kashemirov, Los Angeles, CA (US);

Elena Ferri, Los Angeles, CA (US);

Flore Mietton, Saint Martin d'Heres, FR;

Assignees:

University of Southern California, Los Angeles, CA (US);

CNRS, Paris, FR;

Universite Grenoble Alpes, Saint Martin d'Heres, FR;

INSERM, Paris, FR;

Attorneys:

Haukaas Fortius PLLC

Michael H. Haukaas

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 281/14 (2006.01); C07D 281/16 (2006.01); A61K 31/554 (2006.01); A61K 45/06 (2006.01); A61K 31/437 (2006.01); C07D 471/04 (2006.01); C07D 417/12 (2006.01); A61K 47/10 (2017.01); A61K 9/48 (2006.01); A61K 47/02 (2006.01); C07D 417/14 (2006.01); A61K 47/26 (2006.01); A61K 31/454 (2006.01); A61K 9/20 (2006.01); C07D 513/04 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 47/12 (2006.01); A61P 31/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/554 (2013.01); A61K 9/008 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/06 (2013.01); A61K 9/2018 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 9/485 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 31/437 (2013.01); A61K 31/454 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61P 31/10 (2018.01); C07D 281/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 513/04 (2013.01); C07B 2200/07 (2013.01); C07B 2200/13 (2013.01);
Abstract

The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.

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