The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2021
Filed:
Jul. 06, 2018
Applicant:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Inventors:
Eduardo M. Sotomayor, Tampa, FL (US);
Alejandro V. Villagra, Tampa, FL (US);
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/505 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61K 31/17 (2006.01); A61K 31/416 (2006.01); A61K 31/422 (2006.01); A61K 31/437 (2006.01); A61K 31/454 (2006.01); A61K 31/69 (2006.01); C12N 5/0783 (2010.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 31/505 (2013.01); A61K 31/17 (2013.01); A61K 31/416 (2013.01); A61K 31/422 (2013.01); A61K 31/437 (2013.01); A61K 31/454 (2013.01); A61K 31/69 (2013.01); A61K 39/0011 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/57 (2013.01); A61K 2039/585 (2013.01); C12N 2501/065 (2013.01); C12N 2501/2302 (2013.01);
Abstract
Disclosed are methods whereby an effective amount of a HDAC6 inhibitor is used to activate a subjects T-cell response to tumor or tumor vaccine. Methods of using HDAC6 inhibitors to increase a subjects anti-tumor immune response, alone or in conjunction with other tumor treatments, are also disclosed.