The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2021
Filed:
Nov. 12, 2015
Applicant:
Lek Pharmaceuticals D.d., Ljubljana, SI;
Inventors:
Uro{hacek over (s)} Jamnikar, Menges, SI;
Kristina Gruden, Ljubljana, SI;
Assignee:
Lek Pharmaceuticals d.d., Ljubljana, SI;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6888 (2018.01); G01N 33/50 (2006.01); C12N 5/073 (2010.01);
U.S. Cl.
CPC ...
C12Q 1/6888 (2013.01); C12N 5/0603 (2013.01); G01N 33/5023 (2013.01); C12N 2510/02 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/71 (2013.01); G01N 2333/90666 (2013.01);
Abstract
The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Hist1h2bc, Egrl, BX842664.2/Hist 1h3c, Dhfr, Fgfr2, AC115880.11, Mmp10, Vsnll (optional), CU459186.17, El 30203 B14Rik, Cspg4, C1qtnf1, Foxp2, and Ptpre.