The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2021
Filed:
Feb. 13, 2014
Applicant:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Inventors:
Maria Graca Almeida-Porada, Winston-Salem, NC (US);
Pedro Miguel A. M. Baptista, Winston-Salem, NC (US);
Shay Soker, Greensboro, NC (US);
Assignee:
WAKE FOREST UNIVERSITY HEALTH SCIENCES, Winston-Salem, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/0789 (2010.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0671 (2013.01); C12N 5/0068 (2013.01); C12N 5/067 (2013.01); C12N 5/0647 (2013.01); C12N 2501/01 (2013.01); C12N 2501/04 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/12 (2013.01); C12N 2501/125 (2013.01); C12N 2501/235 (2013.01); C12N 2501/26 (2013.01); C12N 2501/30 (2013.01); C12N 2501/305 (2013.01); C12N 2501/315 (2013.01); C12N 2501/727 (2013.01); C12N 2501/998 (2013.01); C12N 2501/999 (2013.01); C12N 2533/90 (2013.01);
Abstract
An in vitro liver organoid is provided along with methods of making and using the organoid. A cell culture system that includes the liver organoid is also provided. The liver organoid has fetal liver characteristics and supports expansion and differentiation of hematopoietic stem cells.