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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10913767 B1

PDFFull Text
Date of Patent:
Feb. 09, 2021

Filed:

Apr. 22, 2011

Oligonucleotides comprising acyclic and abasic nucleosides and analogs

Applicants:

Muthiah Manoharan, Cambridge, MA (US);

Kallanthottathil G. Rajeev, Cambridge, MA (US);

Jeremy Lackey, Cambridge, MA (US);

Narayanannair K. Jayaprakash, Cambridge, MA (US);

Inventors:

Muthiah Manoharan, Cambridge, MA (US);

Kallanthottathil G. Rajeev, Cambridge, MA (US);

Jeremy Lackey, Cambridge, MA (US);

Narayanannair K. Jayaprakash, Cambridge, MA (US);

Assignee:

ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);

Attorneys:

Jeffrey N. Townes

Cozen O'Connor

Primary Examiner:

Richard A Schnizer

Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/00 (2006.01); C07F 9/6512 (2006.01); C07F 9/655 (2006.01); C07F 9/6558 (2006.01); C07H 19/20 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C07F 9/6512 (2013.01); C07F 9/6552 (2013.01); C07F 9/65583 (2013.01); C07H 19/20 (2013.01); C07H 21/00 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/32 (2013.01); C12N 2310/332 (2013.01);
Abstract

This invention relates to an oligonucleotide comprising one or more abasic nucleoside monomers of formula V: These monomers are useful for modifying of oligonucleotides at one or more positions. This invention also relates to a method of inhibiting the expression of a target gene in a cell. The method comprises contacting the cell with an oligonucleotide having one or more of the above formula (V).

Find Patent Forward Citations

Manoharan, Muthiah. (2021). Oligonucleotides comprising acyclic and abasic nucleosides and analogs (U.S. Patent No. 10913767). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10913767

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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