The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 09, 2021

Filed:

May. 30, 2018
Applicant:

Universita' Di Pisa, Pisa, IT;

Inventors:

Francesco Berti, San Giuliano Terme, IT;

Mauro Pineschi, Certaldo, IT;

Andrea Menichetti, Leghorn, IT;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/08 (2006.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); A61P 3/10 (2018.01);
Abstract

The present invention relates to compounds having structural formula (I) wherein Rand Rare defined as set forth in the description. The invention also relates to a process for the manufacture of the above compounds of formula (I), wherein a 4a,7,8,8a-tetrahydropyrido[4,3-e]-1,4,2-dioxazine reacts with a hydride selected from the group consisting of: lithium triethylborohydride (LiBHEt), sodium triethylborohydride (NaBHEt), and lithium tetrahydroaluminate (LiAlH), in the presence of tetrahydrofuran. Furthermore, the invention is aimed at the above compounds of formula (I), or pharmaceutically acceptable salts thereof, for use in medicine, preferably in the treatment of the diabetes and pathologies or conditions correlated thereto.


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