The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2021
Filed:
Jan. 11, 2018
Max-planck-gesellschaft Zur Forderung Der Wissenschaften E.v., Munich, DE;
Herbert Waldmann, Dortmund, DE;
Pablo Antonio Martin-Gago, Salamanca, ES;
Sandip Murarka, West Bengal, IN;
Christian Klein, Dortmund, DE;
Philippe Bastiaens, Wuppertal, DE;
Alfred Wittinghofer, Herdecke, DE;
Eyad Kalawy Fansa, Dortmund, DE;
Abstract
The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6δ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6δ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.