The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 09, 2021

Filed:

Apr. 05, 2018
Applicants:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Glg Pharma, Llc, Jupiter, FL (US);

Mriglobal, Kansas City, MO (US);

Inventors:

Robert H. Shoemaker, Boyds, MD (US);

Michael W. Lovell, St. Johns, FL (US);

Jonathan M. White, Pleasant Valley, MO (US);

Shanker Gupta, Bethesda, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 309/73 (2006.01); A61P 35/00 (2006.01); C07C 215/10 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01);
U.S. Cl.
CPC ...
C07C 309/73 (2013.01); A61K 9/0053 (2013.01); A61K 9/08 (2013.01); A61P 35/00 (2018.01); C07C 215/10 (2013.01); C07B 2200/13 (2013.01);
Abstract

Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.


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