The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2021
Filed:
Sep. 02, 2016
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Moritz F. Kircher, Boston, MA (US);
Erik Renström, Landskrona, SE;
Martin Koch, Valby, DK;
Ernst Stetter, Seeheim-Jugenheim, DE;
Thomas Reis, Kleinheubach, DE;
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Abstract
The present disclosure describes systems, apparatus, and methods for application of dynamic magnetic field (DMF) treatment to direct movement, and specifically rotation, of magnetic particles associated with a target structure, so that mechanical force is applied to the target structure. In certain embodiments, the present disclosure demonstrates application of DMF treatment to direct rotation about the axis in individual magnetic particles (e.g., superparamagnetic nanoparticles), effecting permeabilization and/or other disruption of membranes (e.g., cell membranes and/or intracellular membranes). In certain embodiments, the present disclosure describes use of an alternating current superconductor (ACSC) to greatly enhance the magnetic field amplitude so that the field can penetrate deeper into a body with sufficient amplitude to control movement of the nanoparticles within a working volume.