The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2021
Filed:
Nov. 27, 2013
Applicant:
The University of Chicago, Chicago, IL (US);
Inventors:
Philip P. Connell, Chicago, IL (US);
Brian Budke, Chicago, IL (US);
Jay H. Kalin, Chicago, IL (US);
Michal Pawlowski, Chicago, IL (US);
Alan P. Kozikowski, Chicago, IL (US);
Assignee:
THE UNIVERSITY OF CHICAGO, Chicago, IL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 207/456 (2006.01); A61K 31/402 (2006.01);
U.S. Cl.
CPC ...
A61K 31/402 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); C07D 207/456 (2013.01);
Abstract
The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.