The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 09, 2021

Filed:

Nov. 07, 2014
Applicants:

Yunjie Tong, Belmont, MA (US);

Blaise B. Frederick, Belmont, MA (US);

Inventors:

Yunjie Tong, Belmont, MA (US);

Blaise B. Frederick, Belmont, MA (US);

Assignee:

MCLEAN HOSPITAL CORPORATION, Belmont, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/026 (2006.01); G01R 33/48 (2006.01); A61B 5/055 (2006.01); G01R 33/563 (2006.01); G01R 33/565 (2006.01); A61B 5/00 (2006.01); A61B 5/0295 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0263 (2013.01); A61B 5/0042 (2013.01); A61B 5/0295 (2013.01); A61B 5/055 (2013.01); A61B 5/7207 (2013.01); A61B 5/7246 (2013.01); G01R 33/4806 (2013.01); G01R 33/56366 (2013.01); G01R 33/56509 (2013.01); G01R 33/56545 (2013.01); A61B 2576/026 (2013.01);
Abstract

A system and method for analyzing blood flow in a subject's brain is provided. In some aspects, the method includes analyzing fMRI data to identify signals related to blood flow, and selecting a zero time lag seed regressor using the identified signals. The method also includes correlating the selected seed regressor to identify a subset of the fMRI data that correlates with the seed regressor and is offset in time, combining the subset of the data to determine a time-delayed regressor, and performing repetitions to obtain a number of time-delayed regressors, where for each repetition, the seed regressor is adjusted using a previous time-delayed regressor. The method further includes analyzing the data using the time-delayed regressors to determine blood delivery from vessels across the brain, and generating a report. In some aspects, a second recursive procedure may be performed using an optimized seed regressor obtained from a first recursive procedure.


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