The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Feb. 06, 2019
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Yunxiang Zhu, Bridgewater, NJ (US);
Seng H. Cheng, Natick, MA (US);
Canwen Jiang, Southborough, MA (US);
Luis Z. Avila, Bridgewater, NJ (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/04 (2006.01); C12N 9/96 (2006.01); C12N 9/16 (2006.01); C12N 9/26 (2006.01); A61K 47/54 (2017.01); A61K 38/47 (2006.01);
U.S. Cl.
CPC ...
C12N 9/96 (2013.01); A61K 38/47 (2013.01); A61K 47/549 (2017.08); C07H 15/04 (2013.01); C12N 9/16 (2013.01); C12N 9/2408 (2013.01); C12Y 301/04012 (2013.01); C12Y 302/0102 (2013.01); C12Y 302/01022 (2013.01); C12Y 302/01076 (2013.01);
Abstract
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.