The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Feb. 28, 2017
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
University of Rijeka Faculty of Medicine, Rijeka, HR;
Inventors:
Ofer Mandelboim, Shoham, IL;
Noa S. Kaynan, Kibbutz Barkai, IL;
Pinchas Tsukerman, Jerusalem, IL;
Stipan Jonjic, Rijeka, HR;
Assignees:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/10 (2006.01); C07K 14/705 (2006.01); A61K 39/395 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); G01N 33/574 (2013.01); C07K 2317/24 (2013.01); C07K 2317/30 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); G01N 2333/70596 (2013.01);
Abstract
The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.