The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Dec. 12, 2017
National Research Council of Canada, Ottawa, CA;
Cephalon, Inc., Frazer, PA (US);
Danica Stanimirovic, Ottawa, CA;
Traian Sulea, Kirkland, CA;
Kristin Kemmerich, Ottawa, CA;
David Wilson, Redwood City, CA (US);
Jennifer Stratton, Redwood City, CA (US);
Matthew Pollard, Pullenvale, AU;
Adam Clarke, Sydney, AU;
National Research Council of Canada, Ottawa, CA;
Cephalon, Inc., Frazer, PA (US);
Abstract
The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an existing antibody fragment and uses thereof, and methods of making such molecules. The polypeptides of the present invention show enhanced blood-brain barrier crossing and brain exposure levels in vitro and in vivo.