The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Oct. 25, 2018
Applicant:
Novo Nordisk A/s, Bagsvaerd, DK;
Inventors:
Vibeke Westphal Stennicke, Kokkedal, DK;
Christine Brender Read, Solborg, DK;
Joseph Leon Kuijper, Kenmore, WA (US);
Xiaoting Tang, Seattle, WA (US);
Mark Heipel, Seattle, WA (US);
Siv Annegrethe Hjorth, Virum, DK;
Assignee:
NOVO NORDISK A/S, Bagsvaerd, DK;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01);
Abstract
Disclosed herein is a method for identifying TREM-1's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1's ligand. Antibodies that reduce or block TREM-1 activation may be identified and selected using this method. Antibodies that bind to TREM-1's ligand and reduce TREM-1 activity may be suitable for use as medicaments.