The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Oct. 28, 2016
Aduro Biotech, Inc., Berkeley, CA (US);
Novartis Ag, Basel, CH;
George Edwin Katibah, Fremont, CA (US);
David Kanne, Corte Madera, CA (US);
Leonard Sung, San Mateo, CA (US);
Kelsey Gauthier, Alameda, CA (US);
Laura Hix Glickman, Oakland, CA (US);
Justin Leong, Union City, CA (US);
Sarah M. McWhirter, Albany, CA (US);
Thomas W. Dubensky, Jr., Berkeley, CA (US);
Jeffrey McKenna, Carlisle, MA (US);
Stephen M. Canham, Cambridge, MA (US);
Chudi Obioma Ndubaku, Oakland, CA (US);
CHINOOK THERAPEUTICS, INC., Berkeley, CA (US);
NOVARTIS AG, Basel, CH;
Abstract
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2'- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.