The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 02, 2021

Filed:

Jan. 08, 2016
Applicants:

Linkun an, Guangzhou, CN;

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Linkun An, Guangzhou, CN;

Christophe Marchand, Silver Spring, MD (US);

Yves Pommier, Bethesda, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/048 (2006.01); C07D 471/04 (2006.01); A61K 31/122 (2006.01); C07D 498/04 (2006.01); C07D 491/04 (2006.01); A61K 31/498 (2006.01); A61K 31/475 (2006.01); A61K 31/47 (2006.01); A61K 31/136 (2006.01); A61K 31/7048 (2006.01); A61K 31/194 (2006.01); A61K 31/704 (2006.01); A61K 31/343 (2006.01); A61K 31/473 (2006.01); A61K 31/4741 (2006.01); A61K 31/4745 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 221/08 (2006.01); C07D 307/92 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); A61K 31/122 (2013.01); A61K 31/136 (2013.01); A61K 31/194 (2013.01); A61K 31/343 (2013.01); A61K 31/47 (2013.01); A61K 31/473 (2013.01); A61K 31/475 (2013.01); A61K 31/4741 (2013.01); A61K 31/4745 (2013.01); A61K 31/496 (2013.01); A61K 31/498 (2013.01); A61K 31/5377 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 45/06 (2013.01); C07D 221/08 (2013.01); C07D 307/92 (2013.01); C07D 471/04 (2013.01); C07D 491/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed Formula I. The variables X, X, and Rare disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula I are also disclosed.


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