The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Oct. 13, 2017
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, CN;
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Shanghai Yu, Shanghai, CN;
Fanglong Yang, Shanghai, CN;
Jingjing Yan, Shanghai, CN;
Xiao Wu, Shanghai, CN;
Feng He, Shanghai, CN;
Weikang Tao, Shanghai, CN;
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, CN;
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Abstract
The present invention relates to a five-membered heteroaryl ring bridged ring derivative, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a new five-membered heteroaryl ring bridged ring derivative as shown in formula (I), a preparation method therefor and a pharmaceutical composition comprising the derivative, and the use thereof as a therapeutic agent, in particular as a TGF-β inhibitor, and the use in the preparation of a drug for treating, preventing or reducing cancers mediated by the over-expression of TGF-β, wherein the definition of each substituent in the general formula (I) is the same as defined in the description.