The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Jun. 18, 2019
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Patrick Joseph Pagano, Sewickley, PA (US);
Peter Wipf, Pittsburgh, PA (US);
Maria Eugenia Cifuentes-Pagano, Sewickley, PA (US);
Erin M. Skoda, Columbia, MD (US);
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof: wherein '' represents a single or double bond, Ris hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ris hydrogen, —CHR, R, or —SOR; Ris lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ris substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ris lower aliphatic, or substituted or unsubstituted aryl; and Ris hydrogen, halogen, or lower aliphatic.