The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Dec. 02, 2019
Applicant:
Sealantium Medical Ltd., Netanya, IL;
Inventors:
Assignee:
SEALANTIUM MEDICAL LTD., Rosh HaAyin, IL;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/70 (2006.01); A61K 38/36 (2006.01); A61K 38/48 (2006.01); A61K 33/14 (2006.01); A61L 15/32 (2006.01); A61L 15/26 (2006.01); A61L 15/38 (2006.01); A61L 15/64 (2006.01);
U.S. Cl.
CPC ...
A61L 15/32 (2013.01); A61L 15/26 (2013.01); A61L 15/38 (2013.01); A61L 15/64 (2013.01); A61K 9/7069 (2013.01); A61K 38/4833 (2013.01);
Abstract
An improved fibrinogen-based tissue sealing patch having a degradation time of less than two weeks is disclosed. The patch comprises a polyethylene glycol-caprolactone-lactide (PEG-CL-LA) triblock copolymer film in which the PEG-CL-LA units are preferably connected by urethane linkages and into a surface of which a fibrinogen-based sealant comprising less than 8 mg/cmfibrinogen and less than 10 IU/cmthrombin has been incorporated. In preferred embodiments, the polymer film comprises PEG having a molecular weight of between 3000 and 3500 and a CL:LA:PEG ratio of 34:2:1. Methods of production and use of the patch are also disclosed.