The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Nov. 17, 2015
Jiangsu Hengrui Medicine Co., Ltd., Jiangsu, CN;
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Xiangdong Qu, Shanghai, CN;
Xin Ye, Shanghai, CN;
Qiyue Hu, Shanghai, CN;
Dongbing Cui, Shanghai, CN;
Weikang Tao, Shanghai, CN;
Lianshan Zhang, Shanghai, CN;
Piaoyang Sun, Jiangsu, CN;
Abstract
An interleukin 15 (IL-15) protein complex is provided. The IL-15 protein complex includes soluble fusion proteins (I) and (II), wherein the fusion protein (I) is an IL-15 polypeptide or a functional fragment thereof, and the soluble fusion protein (II) is an IL-15Rα polypeptide or a functional fragment thereof. The soluble fusion protein (I) has at least one amino acid residue mutated to a cysteine (Cys) residue, which pairs with a corresponding mutated Cys residue on the soluble fusion protein (II), or vice versa, to form one or more disulfide bonds. The IL-15 protein complex can be used for tumor therapy.