The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Sep. 07, 2016
Applicant:
Ecole Polytechnique Federale DE Lausanne (Epfl), Lausanne, CH;
Inventors:
Hongbo Zhang, Guangzhou, CN;
Keir Menzies, Luskville, CA;
Johan Auwerx, Buchillon, CH;
Dongryeol Ryu, Busan, KR;
Assignee:
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), Lausanne, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/706 (2006.01); A61K 35/34 (2015.01); A23L 33/10 (2016.01); A61K 31/165 (2006.01); A61K 45/06 (2006.01); A61K 31/65 (2006.01); A61K 38/18 (2006.01); A23L 33/13 (2016.01); A61P 21/00 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 31/706 (2013.01); A23L 33/10 (2016.08); A23L 33/13 (2016.08); A61K 31/165 (2013.01); A61K 31/65 (2013.01); A61K 35/34 (2013.01); A61K 38/1825 (2013.01); A61K 45/06 (2013.01); A61P 21/00 (2018.01); C12N 5/0658 (2013.01); C12N 2501/10 (2013.01); C12N 2501/999 (2013.01);
Abstract
The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of muscle stem senescence.