The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Oct. 21, 2016
National Tsing Hua University, Hsinchu, TW;
Li-Wen Wang, Hsinchu, TW;
Tzu-Wei Wang, Hsinchu, TW;
NATIONAL TSING HUA UNIVERSITY, Hsinchu, TW;
Abstract
Provided is a sequentially decomposable polypeptide-based nanocarrier with protective shell for delivery of hydrophobic drugs and preparation thereof. The nanocarrier includes a polypeptide-based long chain copolymer and a polypeptide-based short chain copolymer both assembling into an outer layer of hydrophilic polymer and a polypeptide core, wherein the polypeptide-based long chain copolymer includes a long-chain hydrophilic polymer and a first polypeptide chain; the polypeptide-based short chain copolymer includes a short-chain hydrophilic polymer and a second polypeptide chain; the first and the second polypeptide chains each sequentially includes an acidic amino acid segment, an acid-responsive amino acid segment, and a hydrophobic amino acid segment; the long-chain hydrophilic polymer is conjugated with the first polypeptide chain via an acid-labile linkage; an end of the short-chain hydrophilic polymer is conjugated with an active targeting molecule; and the polypeptide core includes a protective shell of an acid-soluble mineral on the acidic amino acid segment.