The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
Aug. 23, 2018
The Board of Trustees of the University of Illinois, Urbana, IL (US);
University of North Carolina-charlotte, Charlotte, NC (US);
Northeastern University, Boston, MA (US);
Aleksei Aksimentiev, Urbana, IL (US);
Kirill A. Afonin, Charlotte, NC (US);
Meni Wanunu, Boston, MA (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
University of North Carolina—Charlotte, Charlotte, NC (US);
Northeastern University, Boston, MA (US);
Abstract
Provided is a highly multiplex approach to disease condition diagnostics that combines nanopore sensing and nucleic acid nanoparticle (NANP) design and synthesis to detect multiple biomarkers to diagnose diseases. The system works by taking a sample containing biomarkers that is mixed with a plurality of nucleic acid nanoparticle (NANP) populations, with each population designed and synthesized to be able to detect a particular biomarker. Upon incubation, the mixture is used with nanopore measurements, with recordings of the ionic current through the nanopore. The ionic current recordings are analyzed, which determines the presence and/or concentration of biomarkers in the sample.