The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
May. 25, 2016
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);
Biogen Chesapeake, Llc, Cambridge, MA (US);
J. Marc Simard, Baltimore, MD (US);
Sven Jacobson, New York, NY (US);
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America as Represented by the Department of Veterans Affairs, Washington, DC (US);
Biogen Chesapeake, LLC, Cambridge, MA (US);
Abstract
Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1-TRPM4 channel that is upregulated upon the mechanical stimulation.