The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 26, 2021

Filed:

Oct. 13, 2017
Applicant:

University of Cape Town, Cape Town, ZA;

Inventors:

Ann Elizabeth Meyers, Cape Town, ZA;

Anna-Lise Williamson, Cape Town, ZA;

Edward Peter Rybicki, Cape Town, ZA;

Emmanuel Aubrey Margolin, Cape Town, ZA;

Rosamund Chapman, Cape Town, ZA;

Assignee:

University of Cape Town, Cape Town, ZA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 45/06 (2006.01); C07K 16/10 (2006.01); G01N 33/569 (2006.01); A61K 39/42 (2006.01); C07K 14/16 (2006.01); A61K 39/21 (2006.01); C12N 15/82 (2006.01);
U.S. Cl.
CPC ...
C07K 14/162 (2013.01); A61K 39/21 (2013.01); C12N 15/8257 (2013.01); C12N 2740/16051 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01);
Abstract

The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.


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