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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10899744 B1

PDFFull Text
Date of Patent:
Jan. 26, 2021

Filed:

Jun. 01, 2017

Crystalline form of compound suppressing protein kinase activity, and application thereof

Applicant:

Xcovery Holdings, Inc., Palm Beach Gardens, FL (US);

Inventors:

Congxin Liang, Palm Beach Gardens, FL (US);

Yongbin Ma, Hangzhou, CN;

Wei He, Beijing, CN;

Assignee:

XCOVERY HOLDINGS, INC., Palm Beach Gardens, FL (US);

Attorney:

Norton Rose Fulbright US LLP

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A61K 31/506 (2006.01); C07D 403/12 (2006.01); A61K 31/501 (2006.01); A61P 9/00 (2006.01); C07D 403/10 (2006.01); A61P 35/00 (2006.01); A61P 25/00 (2006.01); A61P 3/00 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 31/501 (2013.01); A61P 3/00 (2018.01); A61P 9/00 (2018.01); A61P 25/00 (2018.01); A61P 35/00 (2018.01); C07D 403/10 (2013.01); C07B 2200/13 (2013.01);
Abstract

Provided are a compound as represented by structural formula (I) ({5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-{4-[((3S,5R)-3,5-di methylpiperazinyl)carbonyl]phenyl}carboxamide hydrochloride) and a novel crystalline form of a hydrate or solvate of the compound. Further provided are a manufacturing method of the compound and crystalline form, a related intermediate, a pharmaceutical composition comprising the compound, an application using the compound or the crystalline form for preparing a pharmaceutical product for treating a disease, symptom, or disorder, and a therapeutic method for treating a disease, symptom, or disorder.

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