The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
Jan. 07, 2019
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Philip Jones, Houston, TX (US);
Michael J. Soth, Sugar Land, TX (US);
Jason P. Burke, Houston, TX (US);
Kang Le, Sugar Land, TX (US);
Gang Liu, Sugar Land, TX (US);
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/501 (2006.01); C07D 401/14 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 31/337 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/337 (2013.01); A61K 31/501 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07B 2200/13 (2013.01);
Abstract
Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.