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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10899719 B1

PDFFull Text
Date of Patent:
Jan. 26, 2021

Filed:

Dec. 19, 2019

Aryl or heteroaryl triazolone derivatives or salts thereof, or pharmaceutical compositions comprising the same

Applicant:

Yuhan Corporation, Seoul, KR;

Inventors:

Tae Dong Han, Yongin-si, KR;

Hee Jae Tak, Yongin-si, KR;

Eun Kyung Kim, Hwaseong-si, KR;

Su Bin Choi, Yongin-si, KR;

Dong Hoon Kim, Suwon-si, KR;

Sol Park, Yongin-si, KR;

Eun Hye Jung, Yongin-si, KR;

Hyun Ho Choi, Suwon-si, KR;

Tae Wang Kim, Yongin-si, KR;

Mi Kyeong Ju, Suwon-si, KR;

Na Ry Ha, Seoul, KR;

Assignee:

YUHAN CORPORATION, Seoul, KR;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 249/08 (2006.01); C07D 401/04 (2006.01); C07D 417/04 (2006.01); C07D 409/10 (2006.01); C07D 405/10 (2006.01); C07D 407/14 (2006.01); C07D 401/10 (2006.01); C07D 403/10 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 417/14 (2006.01); C07D 413/14 (2006.01); C07D 413/10 (2006.01); C07D 417/10 (2006.01); C07D 249/12 (2006.01); C07D 403/14 (2006.01);
U.S. Cl.
CPC ...
C07D 249/08 (2013.01); C07D 249/12 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/14 (2013.01); C07D 405/10 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/10 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01);
Abstract

The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

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