The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
Jun. 24, 2020
Applicant:
Dizal (Jiangsu) Pharmaceutical Co., Ltd., Shanghai, CN;
Inventors:
Changhe Qi, Shanghai, CN;
Honchung Tsui, Shanghai, CN;
Qingbei Zeng, Shanghai, CN;
Zhenfan Yang, Shanghai, CN;
Xiaolin Zhang, Shanghai, CN;
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/497 (2006.01); A61K 31/136 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); A61K 31/501 (2006.01); C07D 405/04 (2006.01); C07D 401/04 (2006.01); C07D 417/14 (2006.01); A61K 39/395 (2006.01); A61K 33/243 (2019.01); A61K 31/337 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/497 (2013.01); A61K 31/136 (2013.01); A61K 31/337 (2013.01); A61K 31/501 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 33/243 (2019.01); A61K 39/3955 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract
The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.