The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 26, 2021

Filed:

Jun. 21, 2017
Applicant:

Epirium Bio Inc., San Diego, CA (US);

Inventors:

Sundeep Dugar, San Jose, CA (US);

George Schreiner, Los Altos Hills, CA (US);

Somdutta Sen, Manesar, IN;

Assignee:

Epirium Bio Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/353 (2006.01); C07D 311/62 (2006.01); A61P 21/00 (2006.01); A61P 9/10 (2006.01); A61P 25/28 (2006.01); A61P 1/16 (2006.01); A61P 25/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/353 (2013.01); A61P 1/16 (2018.01); A61P 9/10 (2018.01); A61P 21/00 (2018.01); A61P 25/08 (2018.01); A61P 25/28 (2018.01); C07D 311/62 (2013.01);
Abstract

The present invention pertains to the enhanced activity of (+) epicatechin over (−) epicatechin. The present invention is related to novel analogs of (+) epicatechin of the formula (I), which enhances the pharmacokinetics and therefore the pharmacodynamics of (+) epicatechin. The present invention is related to analogs of (+) epicatechin of the formula (I). The general structure of the analogs of the present invention may be represented by Formula (I): Formula (I) wherein A and B are independently OR1 and C and D are independently OH; wherein R1 is independently C1 to C10 lower straight or branched chain acyclic or cyclic alkyl, or is selected from the group comprising, hydroxy butyric acid, dichloroacetic acid; phenyl butyric acid; valproic acid.


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