The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
Dec. 21, 2016
Applicant:
The Texas A&m University System, College Station, TX (US);
Inventors:
Akhilesh K. Gaharwar, Cypress, TX (US);
James K. Carrow, College Station, TX (US);
Assignee:
The Texas A&M University System, College Station, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 9/00 (2006.01); C08K 3/34 (2006.01); A61K 9/14 (2006.01); C12N 5/077 (2010.01); A61K 35/28 (2015.01); A61K 35/32 (2015.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 9/5161 (2013.01); A61K 9/0024 (2013.01); A61K 9/14 (2013.01); A61K 9/5115 (2013.01); A61K 35/28 (2013.01); A61K 35/32 (2013.01); A61K 47/6923 (2017.08); C08K 3/34 (2013.01); C12N 5/0655 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01); C08K 2201/011 (2013.01); C12N 2500/05 (2013.01); C12N 2506/1353 (2013.01); C12N 2533/10 (2013.01);
Abstract
Aspects of the invention are directed to mineral-based nanoparticles comprising silicate nanoparticles that induce human mesenchymal stem cells (hMSCs) into a cartilage-lineage through the upregulation of cartilage-specific genes resulting in the transformation of the cell phenotype into that of a chondrocyte, i.e., a cartilage producing cell. The silicate nanoparticles are synthesized through a process where the precipitate of sodium silicate is mixed with one or more elements and compounds and milled into nanoparticles.