The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2021
Filed:
May. 24, 2018
Topas Therapeutics Gmbh, Hamburg, DE;
Barbara Freund, Hamburg, DE;
Jörg Heeren, Hamburg, DE;
Peter Nielsen, Besitz, DE;
Antonella Carambia, Hamburg, DE;
Johannes Herkel, Hamburg, DE;
Oliver Bruns, Boston, MA (US);
Ansgar Lohse, Hamburg, DE;
Stefan Lüth, Hamburg, DE;
Horst Weller, Hamburg, DE;
Sunhild Salmen, Hamburg, DE;
Topas Therapeutics GmbH, Hamburg, DE;
Abstract
The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.